Vivotif Oral Typhoid Vaccine (Typhoid Vaccine Live Oral Ty21a)
Before You Depart, Help Protect Yourself Against Typhoid Fever
Sampling local cuisine can be one of the most enjoyable parts of traveling; however, when it comes to food and drink, you should understand the risk that typhoid fever can present. Please see use and Important Safety Information below and continued throughout.
What is VIVOTIF used for?: VIVOTIF is a prescription vaccine you take by mouth to help protect you from typhoid fever. Typhoid fever, which can be a life-threatening disease, is caused by a specific type of bacteria. VIVOTIF is for adults and children more than 6 years of age. Use and Important Safety information continued below.
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VIVOTIF Is the Only FDA-Approved Oral Vaccine for Typhoid Fever
VIVOTIF is a prescription vaccine you take by mouth to help protect you from typhoid fever. Typhoid fever, which can be a life-threatening disease, is caused by a specific type of bacteria. Immunization with VIVOTIF is not routinely recommended for people living in the United States; however, VIVOTIF is recommended for people who are at a higher risk of getting typhoid fever.
Use and Important Safety Information for VIVOTIF® (vee-voh-TEEF) continued: It is also known as Typhoid Vaccine, Live, Oral Ty21a Immunization with VIVOTIF is not routinely recommended for people living in the United States; however, VIVOTIF is recommended for people who are at a higher risk of getting typhoid fever. Use and Important Safety information continued below.
VIVOTIF Can Help Provide Protection When the Full Course Is Taken at Least 1 Week Prior to Traveling
- For people who travel to places where typhoid fever is more common
- For people who have close contact with someone who has had typhoid fever or is known to be carrying the bacteria that causes it
- For people who work in laboratories who could have contact with the bacteria that causes typhoid fever (Salmonella typhi)
Use and Important Safety Information Continued:
This includes:
- People who travel to places where typhoid fever is more common
- People who have close contact with someone who has had typhoid fever or is known to be carrying the bacteria that causes it
- People who work in laboratories who could have contact with the bacteria that causes typhoid fever (Salmonella typhi)
Use and Important Safety information continued below.
Use and Important Safety Information for VIVOTIF® Continued:
VIVOTIF is an oral vaccine. One complete dosing schedule
consists of 4 capsules. VIVOTIF is taken every other day for 7 days.
(see illustration below)
Swallow one capsule about 1 hour before a meal with a cold or lukewarm (temperature not to exceed body temperature, e.g., 37°C [98.6°F]) drink. It doesn’t matter what time you take your capsule, as long it’s at least 1 hour before a meal:
- Swallow the capsule as soon after placing in the mouth as possible. Don't open or chew capsule
- Do not freeze the capsules. Keep capsules refrigerated (35.6ºF–46.4ºF) until you're ready to take them
Can I take VIVOTIF if I have a stomach or intestinal illness?
If you have a sudden stomach or intestinal illness, postpone taking VIVOTIF and tell your healthcare provider (HCP).
Can I take VIVOTIF if I have ongoing diarrhea or vomiting?
If you are vomiting or have diarrhea that will not stop, do not take VIVOTIF until the vomiting and diarrhea have stopped.
Can I take VIVOTIF if I take other medications?
Tell your HCP about all the prescription and over-the-counter medicines,
vitamins, and herbal supplements you take.
Certain treatments, like antibiotics and some anti-malaria medications, can
interfere with how VIVOTIF works. As needed, your doctor can discuss with
you whether to postpone or decide against taking the vaccine.
How should I take and store the 4 doses of VIVOTIF to get the full protective effect?
It is essential that you take all 4 doses of VIVOTIF, every other day until you complete the series, to ensure that you get the full protective effect of the vaccine. Do not chew the capsule and swallow the capsule as soon as possible once you put it in your mouth. It is also essential to replace unused vaccine in the refrigerator between doses
Can I take VIVOTIF if I am pregnant or nursing?
If you are pregnant, you should take VIVOTIF only if clearly needed because it is not known whether VIVOTIF can cause harm to a developing baby or interfere with a healthy birth. Also, no evidence exists to show that VIVOTIF is safe and effective in nursing mothers, and it is not known if VIVOTIF gets into breast milk.
What are the most common side effects of VIVOTIF?
In clinical trials of people receiving 3 doses of VIVOTIF, the most common
side effects were abdominal pain, nausea, headache, fever, diarrhea,
vomiting, and skin rash. Only nausea was more common in people that took
VIVOTIF compared with those who took a sugar pill.
These are not all the
possible side effects of VIVOTIF. Patients should always ask their
healthcare professionals for medical advice about the appropriate use of
vaccines and adverse events. To report SUSPECTED ADVERSE REACTIONS, contact
Bavarian Nordic at 1‑833‑365‑9596 or the US Department of Health and Human
Services by either visiting www.vaers.hhs.gov/reportevent.html or calling
1‑800‑822‑7967.
Learn More
This summary provides basic information about VIVOTIF, but it does not
include all information known about this vaccine. Talk to your HCP or
pharmacist about this information. Your HCP is the best person to help you
decide if VIVOTIF is right for you.
For more information about VIVOTIF, please see full
Prescribing Information.
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