Scrolled to top

NexGard COMBO Topical Solution Protection for Cats

Next-level protection for cats with NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution)
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution)

NexGard COMBO

NexGard® COMBO protects your cat from parasites. Talk to your vet to see if a NexGard® COMBO prescription is right for your cat.

Use NexGard® COMBO with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, and anorexia.

Exclusive Member Savings on NexGard COMBO

Save up to 80% on prescriptions for the whole family including pets.

Check Prices

Convenient One-&-Done Monthly Parasite Protection

All cats need parasite protection, even indoor cats. Applied monthly, NexGard® COMBO topical solution helps protect your cat year-round. It's the first and only feline broad-spectrum parasite protection that treats taperworms.

Safe for Kittens

Safe for kittens as young as 8 weeks old & weighing at least 1.8 pounds.

Easy to Apply

The topical solution makes application simple. Read full instructions before use.

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution)

Vet Recommended

Talk to your vet about protecting with NexGard COMBO, available by prescription.

Product Details

NexGard COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) for Cats treats fleas and ticks, prevents heartworm disease, and treats and controls hookworms, roundworms and tapeworms. NexGard® COMBO topical solution is parasite protection for cats from the maker of vet-recommended1 NexGard® (afoxolaner) and HEARTGARD® Plus (ivermectin/pyrantel).

All cats need parasite protection, even indoor cats. Applied monthly, NexGard® COMBO is designed to deliver parasite protection to your cat year-round with an easy-to-use applicator. And it’s the first and only broad-spectrum solution for cats that treats and controls tapeworms.

NexGard® COMBO topical solution is one-and-done monthly protection formulated specifically for cats. It is safe and approved for cats and kittens as young as 8 weeks old, weighing 1.8 pounds or more.

  • Year-round protection from harmful parasites when applied monthly
  • Convenient one-and-done monthly dosing
  • First and only feline broad spectrum parasite protection that treats tapeworms
  • Protects against adult fleas before they can lay eggs
  • Protects against black-legged ticks and lone star ticks
  • Effectively prevents heartworm disease
  • Treats and controls hookworms, roundworms, and tapeworms
  • Easy-to-apply topical formulation designed specifically for cats
  • Safe for kittens as young as 8 weeks of age, weighing 1.8 pounds or more

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is dosed at a minimum of 0.055 mL/lb. (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb. (1.44 mg/kg) esafoxolaner, 0.22 mg/lb. (0.48 mg/kg) eprinomectin, and 4.53 mg/lb. (9.98 mg/kg) praziquantel. Administer the entire contents of a NexGard® COMBO unit applicator topically once a month. For heartworm disease prevention, apply once monthly for at least three months after last exposure to mosquitoes.

  1. Use scissors to cut the blister along the dotted line.
  2. Then pull the lid away.
  3. Remove the applicator from the package and hold it upright. Pull back the plunger slightly.
  4. Twist and pull off the cap.
  5. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire contents directly onto the skin in one spot. The product should be applied to dry skin on an area where the cat cannot lick it off. If the weight of the cat requires a second application, apply the contents in the same manner as described above in the same location.
  6. Wash hands after use with soap and water.

Esafoxolaner, eprinomectin and praziquantel

IMPORTANT SAFETY INFORMATION:
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, contact your veterinarian, visit NexGardForPets.com or refer to the full prescribing information.

NexGard® is a registered trademark and NexGard COMBO is a trademark of Boehringer Ingelheim Animal Health France, used under license. ©2025 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. HEARTGARD® and the Dog & Hand logo® are registered trademark of Boehringer Ingelheim Animal Health USA Inc. ©2025 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved.

Frequently Asked Questions

NexGard® COMBO topical solution is a monthly topical solution for cats that provides broad-spectrum protection against external and internal parasites. The three active ingredients, esafoxolaner, eprinomectin, and praziquantel, protect against fleas and ticks, prevent heartworm disease, and treat and control roundworms, hookworms, and tapeworms. NexGard® COMBO comes from the maker of vet recommended NexGard® (afoxolaner) and HEARTGARD® Plus (ivermectin/pyrantel).

Use NexGard® COMBO topical solution by following the instructions and dosage guidelines provided by your veterinarian or refer to the full prescribing information. Each dose provides protection from fleas and ticks, heartworm disease, roundworms, hookworms, and tapeworms.

NexGard® COMBO topical solution is intended for topical application only. Do not inject, do not administer orally or via any other route. Carefully follow the application instructions on the packaging label for best results.

NexGard® COMBO topical solution works fast, protecting against adult fleas before they lay eggs. Although it protects against adult fleas quickly, it may take several weeks to control infestations as the environment may include fleas in earlier stages that have not yet developed into adults.

NexGard® COMBO topical solution is safe for cats and kittens as young as 8 weeks, weighing 1.8 pounds or more.

NexGard® COMBO topical solution is available in packs containing either three or six topical doses and comes in two different sizes: 1) for cats 1.8 to 5.5 pounds, and 2) for cats 5.6 to 16.5 pounds.

Outdoor and indoor cats should be treated with NexGard® COMBO topical solution once a month. Year-round protection is highly recommended. The convenient applicator makes one-and-done monthly dosing easy. NexGard COMBO topical solution protects against fleas and ticks, prevents heartworm disease, and treats and controls hookworms, roundworms, and tapeworms.

Other Popular
Medications

Healthy Pets. Happy Families.

Did you know you can get discounts on other popular pet medications with your Costco card?

Search Pet Medications

Your Costco Card Is Now an Rx Discount Card Too!

Your benefits include discounts for prescription drugs and more!

  • Get exclusive pricing for all Costco members, whether you're insured or not.
  • Save on thousands of prescriptions – get instant savings on prescriptions for family and pets.
  • Save on medical devices and preventative and lifestyle medications.
  • Get savings on most vaccinations.
  • Get discounts on popular medications, nebulizers and diabetic supplies with a prescription.
  • Easy refills, prescription transfers, delivery services and more!
Discount Prescription Guide
Powered by Costco Health Solutions. Costco Member Prescription Program (CMPP) is a direct-to-members savings program administered by Costco Health Solutions, Inc. and Ventegra Inc. Participating pharmacies are subject to change without notice and are not available in all areas. CMPP is not insurance or intended as a replacement for insurance. Claims submitted for coverage under publicly funded programs (e.g. Medicare, Medicaid, etc.) or private insurance are not eligible for CMPP participation. Shipping and handling cost are not included in the price. Costco Health Solutions, Inc. 845 Lake Drive Issaquah, WA 98027 https://www.costcohealthsolutions.com/. Data on file at Boehringer Ingelheim